The dispute centers on a substance known as carbonic anhydrase inhibitors.
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Carbonic anhydrase inhibitors may cause stinging, burning, and eye discomfort.
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This drug can also be used for sleep apnea treatment along with a carbonic anhydrase inhibitor.
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Methazolamide is also a carbonic anhydrase inhibitor.
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Raul Rodriguez, Sponsel's attorney, said Sponsel undertook research into carbonic anhydrase inhibitors, some of it funded by Merck.
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Carbonic anhydrase inhibitors decrease bicarbonate formation from ciliary processes in the eye, thus decreasing the formation of Aqueous humor.
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Fardi Medicals ) is a carbonic anhydrase inhibitor used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
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Sponsel discovered that carbonic anhydrase inhibitors also could increase blood flow within the retina, which would be useful in treating macular edema and macular degeneration.
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The first unequivocal example of the application of structure-based drug design leading to an approved drug is the carbonic anhydrase inhibitor dorzolamide, which was approved in 1995.
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Sulfamates have been used in the design of many types of therapeutic agents such as antibiotics, nucleoside / nucleotide human immunodeficiency virus ( HIV ) reverse transcriptase inhibitors, HIV protease inhibitors ( PIs ), anti-cancer drugs ( steroid sulfatase and carbonic anhydrase inhibitors ), anti-epileptic drugs, and weight loss drugs.
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